Immunization, Vaccines and Biologicals

WHO/V&B/02.18

Haemophilus influenzae type b (Hib) meningitis in the pre-vaccine era : a global review of incidence, age distributions, and case-fatality rates

This document will report on a comprehensive global review of the scientific literature concerning meningitis due to Hib occurring prior to widespread vaccine introduction. The review included information from several hundred studies, including population-based, hospital-based, and surveillance data. Information on incidence in children 0-59 months of age, age patterns of disease, and case fatality rates will be provided, as well as information on antibiotic pre-treatment, where available. Analyses will focus on regional trends. Discussion will point out strengths and limitations of the data.

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