Immunization, Vaccines and Biologicals

Call for proposals - The immunological basis for seasonal influenza immunization

Background

The WHO Initiative for Vaccine Research (IVR) is commissioning the development of “The Immunological Basis for Seasonal Influenza Immunization” document. This document will comprise the influenza vaccine module for WHO “Immunological Basis for Immunization Series”. This Series was initially developed in 1993 as a set of eight modules focusing on the vaccines included in the Expanded Programme on immunization (EPI). In addition to a general immunology module, each of the seven other modules covered one of the vaccines recommended as part of the EPI programme, i.e. diphtheria, measles, pertussis, polio, tetanus, tuberculosis and yellow fever. These modules have become some of the most widely used documents in the field of immunization.

With the development of the Global Immunization Vision and Strategy (2006-2015) and the expansion of immunization programmes in general, as well as the large accumulation of new knowledge since 1993, the series was extended to include additional vaccines. The main purpose of the modules - which are published as separate disease/vaccine specific modules - is to give immunization managers and vaccination professionals a brief and easily-understood overview of the scientific basis of vaccination, and also of the immunological basis for the WHO recommendations on vaccine use that since 1998 are published in the Vaccine Position Papers. For more information about the “Immunological Basis for Immunization” series, please see this link:

Contents of the document should include:

  • Influenza virus biology.
  • Epidemiology of influenza disease.
  • Review of types of seasonal influenza vaccines on the market;
    • To include seasonal LAIV and inactivated influenza vaccines;
    • Note that monovalent 2009 influenza A (H1N1) vaccine and animal influenza vaccines (such as those against H5 and H7) are outside the intended scope of this document.
  • Review of seasonal influenza vaccine safety and performance;
  • Influenza vaccine policy and programmatic use.
    • Please note that IVR wishes to avoid undue overlap with the current WHO Influenza Vaccine Position Paper:
  • Future prospects for influenza vaccine, to include considerations for use in tropical and low-resource settings.

It is anticipated that this document will be around 15,000 words.

Proposals

IVR requests proposals to complete the above work. Proposals should include:

  • description of proposed author knowledge and experience regarding influenza vaccines;
  • references to sample documents written by the authors;
  • tentative outline of the document; and
  • detailed budget and timelines.

IVR will choose the winning proposal based on author experience, proposed contents, and budget.

Tentative timelines

  • WHO call for proposals: 24 June 2014 – 25 July 2014.
  • Proposal chosen by WHO: 1 August 2014.
  • Author progress report: 3 December 2014.
  • First draft to WHO: 2 February 2015.
  • WHO edits to authors: 15 February 2015.
  • Author response to WHO: 16 March 2015.
  • External peer review: 16 March 2015 – 16 May 2015.
  • Author response to external peer review: 15 June 2015.
  • 2nd external peer review (if needed): 15 June 2015 – 15 July 2015.
  • Finalization of document 1 August 2015.

To submit a proposal, please follow the link below to the “Proposal instructions”. Email all proposals to ortizj@who.int for consideration by 25 July 2014.

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