Immunization, Vaccines and Biologicals

Systematic review of missed opportunities for vaccination

Request For Proposals

Research objectives

The primary objectives of this RFP are:

  • to solicit the review, evaluation and summarization of data regarding the frequency and reasons for missed opportunities for vaccination among children and women of child bearing age;
  • to assess and document the magnitude of missed opportunities for vaccination in low and middle income countries (LMICs) – that is, estimate the proportion of additional children that could be immunized in LMICs using existing services if missed opportunities were avoided.

Successful applicant teams will use replicable search strategies to perform a systematic review of the peer reviewed literature in order to include all relevant studies. The review should be conducted in accordance with international standards for the conduct and reporting of systematic reviews (e.g. COCHRANE), and should include but need not be limited to the following objectives:

  • Perform a systematic review of the peer reviewed literature to identify relevant publications and sources reporting relevant data.
  • Critically appraise the published literature with regard to the appropriateness of the methodology and the analyses performed, and how this may have influenced any conclusions.
  • As appropriate, perform quantitative or qualitative syntheses of the available evidence and identify areas where key evidence is lacking.
  • There is also particular interest in the evaluation of data quality. The review groups may consider issues in the collection of these data, including ascertainment biases, and identify opportunities for improvements in future studies. The quality of the data should be an important focus of this effort.