SAGE meeting of April 2012
SalleA, CCV, Geneva, 10-12 April 2012
Background documents
Session: Report from Director, IVB
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SAGE report of November 2011 meeting
pdf, 870kb -
SAGE report from the DoV meeting of February 2012
pdf, 299kb -
SAGE tracking record of recommendations and action points
pdf, 481kb -
Draft Global Vaccins Action Plan, 19 March 2012
pdf, 923kb -
Immunization and Vaccines related Implementation Research Advisory Committee (IVIR-AC) - Terms of reference
pdf, 254kb -
TFI members' meeting, Summary report, Windhoek, Namibia, 2-3 December 2011
pdf, 660kb
Session: Reports from other advisory committees on immunization
Session: Polio eradication
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Wild poliovirus map - last six months (21 September 2011 - 20 March 2012)
pdf, 165kb -
Report Of The Independent Monitoring Board Of The Global Polio Eradication Initiative - February 2012
pdf, 1.06Mb -
Background paper on switch from 'tOPV to bOPV' for routine immunization - SAGE Working Group
pdf, 456kb -
First Meeting of the Pakistan Technical Advisory Group on Polio Eradication Islamabad, 21 & 22 March 2012: Brief Summary & Recommendations
pdf, 297kb -
23rd Meeting of the Expert Review Committee (ERC) on Polio Eradication Initiative & Routine Immunization: Major Findings & Recommendations
pdf, 55kb -
Global Polio Emergency Action Plan 2012-13
pdf, 1.74Mb
Session: Seasonal influenza vaccine
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Background paper on Influenza Vaccines and Immunization SAGE Working Group
pdf, 692kb -
4th Meeting Of The Sage Working Group On Influenza Vaccines And Immunization, 14 – 15 February 2012
pdf, 553kb -
Minutes of the 2nd meeting of the SAGE Working Group on influenza vaccine and immunization
pdf, 201kb
WHO HQ, 14-15 February 2011 -
WHO position paper on influenza vaccines
pdf, 220kb - Nair H, et al. Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis. Lancet. 2011 Dec 3;378(9807):1917-30. Epub 2011 Nov 10.
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Minutes of the Aug 2011 meeting of the SAGE Working Group on influenza vaccines and immunization
pdf, 206kb - Zaman K, et al.Effectiveness of maternal influenza immunization in mothers and infants. N Engl J Med. 2008 Oct 9;359(15):1555-64. Epub 2008 Sep 17
- Vaccines for preventing influenza in the elderly (Review), Jefferson T, Di Pietrantonj C, Al-Ansary LA, Ferroni E, Thorning S, Thomas RE (Cochrane Review)
- Vaccines for preventing influenza in healthy children (Review). Jefferson T, Rivetti A, Harnden A, Di Pietrantonj C, Demicheli V. (Cochrane Review)
Session: Impact of introduction of new vaccines on the strengthening of immunization and health systems
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Summary of main themes and findings from review of 5 data sources by WHO health system building blocks
pdf, 571kb -
Executive summary of data sources: Published literature review
pdf, 109kb -
Executive summary of data sources: Grey literature review
pdf, 121kb -
Executive summary of data sources: In-depth study of 3 countries
pdf, 118kb -
Executive summary of data sources: Interviews with key informants from countries and regions
pdf, 101kb -
Executive summary of data sources: Analysis of DTP3 coverage
pdf, 102kb -
Principles for adding a vaccine to a national immunization programme while strengthening the immunization and health systems
pdf, 49kb -
Selected parts of the updated WHO tool for countries: Principles and considerations for adding a vaccine to a National Immunization Programme
pdf, 204kb
Session: Vaccination in humanitarian emergencies
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Vaccination in Humanitarian Emergencies: Literature review and case studies
pdf, 983kb -
Ethical Considerations for Vaccination Programmes in Acute Humanitarian Emergencies
pdf, 275kb -
A Framework for Deciding on Vaccinations in Acute Emergencies
pdf, 514kb
Session: Rotavirus vaccine schedules
- Expanding the potential of rotavirus vaccines (RV) to reduce mortality by optimizing the immunization schedules
- Soares K et al (2012) Vaccines for preventing rotavirus diarrhoea: vaccines in use
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Soares K et al (2012). Rotavirus vaccine schedules: a systematic review of safety and efficacy from RCTs and observational studies of childhood schedules using RV1 and RV5 vaccines- Report to WHO/IVR
pdf, 23.75Mb -
Sanderson C et al (2011) Global review of rotavirus morbidity and mortality data by age and WHO region. Report to WHO/IVR
pdf, 3.12Mb - De Oliveria L et al (2011) Progress in the Introduction of the Rotavirus Vaccine in Latin America and the Caribbean Four Years of Accumulated Experience The Pediatric Infectious Disease Journal • Volume 30, Number 1, January 2011
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Patel M et al (2012). Age restrictions for rotavirus vaccination: evidence-based analysis of rotavirus mortality reduction versus risk of fatal intussusception by mortality stratum. Report to WHO/IVR
pdf, 1.08Mb - Patel M (2011) Intussusception risk and health benefits of rotavirus vaccination in Mexico and Brazil New England Journal of Medicine 364:24 (2283-2292)
- Patel M et al (2009) Broadening the age restrictions for initiating rotavirus vaccination in regions with high rotavirus mortality: benefits of mortality reduction versus risk of fatal intussusception Vaccine 27 (2916-2922)
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Table: Rotavirus vaccines efficacy and effectiveness by WHO mortality strata - List of included studies
pdf, 1.03Mb -
Table: Rotavirus disease epidemiology and potential to provide one or more doses of vaccine to children by week of age: Country level estimates –examples from countries with data available
pdf, 195kb -
Data on intussusception after vaccination with RV: RCTs and observational studies
pdf, 1.01Mb
Session: Use of hepatitis A vaccines
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Evidence for the use of single dose inactivated hepatitis A vaccine schedules: Background paper for SAGE decision Addendum to SAGE Hepatitis A Working Group report to SAGE November 2011
pdf, 22kb -
Background paper prepared for the November 2011 SAGE meeting
pdf, 89kb -
GRADE table: Efficacy and safety of hepatitis A vaccines
pdf, 55kb -
GRADE table: Hepatitis A vaccine and post-exposure prophylaxis
pdf, 29kb -
GRADE table: Population impact of Hepatitis A immunization programs
pdf, 37kb -
GRADE table: Hepatitis A vaccines and long-term protection
pdf, 40kb - The Immunological Basis for Immunization Series: Hepatitis A
Session: Report from the GAVI Alliance Secretariat
Session: Information on vaccines for an Intergovernmental Negotiating Committee on Mercury
The following materials are from presentations and statements made at the WHO informal Consultation to develop further guidance on vaccines for the UNEP-convened Intergovernmental Negotiating Committee Meeting 4, WHO-HQ, 3-4 April 2012
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Statement by SafeMinds
pdf, 1.74Mb -
Statement by CoMeds
pdf, 184kb -
Setting the scene
pdf, 4.43Mb
D. Wood -
Updates on (a) the safety profile of thiomersal; (b) the biological plausibility of thiomersal contributing to cumulative mercury toxicity
pdf, 1.43Mb
R. Mitkus -
Safety profile of thiomersal and the safety of alternative preservatives
pdf, 366kb
M. Pichichero -
Experience with alternatives to thiomersal from other fields (eg biotherapeutics; veterinary vaccines)
pdf, 1.50Mb
J. Löwer -
Alternatives to thiomersal as preservatives for vaccines
pdf, 247kb
G. Cirefice on behalf of EDQM and D. Meek -
The R&D pipeline for alternative preservatives
pdf, 656kb
G V. Bossche -
Assessing the impact of preservative-free vaccine on the immunization supply chain
A. Battersby -
Trends in use of multi-dose vaccine vials
pdf, 795kb
J. Liu -
Regulators perspectives on alternatives to thiomersal
pdf, 1.36Mb
USFDA -
Regulators perspectives on alternatives to thiomersal
pdf, 171kb
EMA -
NIFDC's comments on the use of thiomersal in vaccines
pdf, 670kb
J. Wang -
Procurement agencies perspectives on alternatives to thiomersal
pdf, 1.04Mb
UNICEF -
Procurement agencies perspectives on alternatives to thiomersal
pdf, 990kb
PAHO Revolving Fund -
Manufacturing perspectives on alternatives to thiomersal
pdf, 197kb
Novartis, Sanofi Pasteur, Crucell -
Manufacturing perspectives on alternatives to thiomersal
pdf, 138kb
DCVMN -
Manufacturing perspectives on alternatives to thiomersal
pdf, 1.38Mb
IFAH -
Timerosol: Problems, costs and solutions
pdf, 164kb
G. de Chile -
Meeting summary: Sessions 1 and 2
pdf, 79kb -
Meeting summary: Sessions 3 and 4
pdf, 164kb