Immunization, Vaccines and Biologicals

Helicobacter pylori

The isolation of Helicobacter pylori from the human gastric mucosa in 1982 and the demonstration of its involvement in gastritis, peptic ulcer disease and gastric adenocarcinomas have radically changed our perception of these diseases. H. pylori is a small, spiral, gram-negative bacillus that appears to inhabit the mucous layer overlying the gastric epithelial cells in humans. It produces a potent urease, which, by producing ammonia, may help to neutralize gastric acid, but the mechanism by which the bacteria produces gastric inflammation is not clear as it does not invade the mucosa. Development of atrophy and metaplasia of the gastric mucosa are strongly associated with H. pylori infection. Oxidative and nitrosative stress in combination with inflammation plays an important role in gastric carcinogenesis. More

Last updated: 25 Janury 2008