Immunization standards

Typhoid (20 dose vial)

Vaccine Trade Name: TYPHIM-Vi

Vaccine Type: Polysacharide typhoid vaccine

Manufacturer: Sanofi Pasteur

Country of Manufacture: France

Date of prequalification: 1 June 2011

NRA of Record: ANSM

Product Description

Pharmaceutical form: liquid

Presentation: 20 dose vial

Route of administration: intramuscular

Vaccine Vial Monitor: type 30

Shelf life: 36 months at 2 - 8 °C

Secondary Packaging:

Cold Chain volume per dose (cm3): 1.58

Preservative: Phenol ≤1.250 mg/0.5 ml.

Handling of opened multi-dose vials: WHO recommends that opened vials of this vaccine should be discarded 6 hours after opening or at the end of the immunization session, whichever comes first.

Remarks

The labelling system (e.g.: package insert) of TYPHIM Vi (polysaccharide typhoid vaccine) indicates that any open vial remaining at the end of the immunization session (this is after 6 hours after first opening) should be discarded. The vaccine is presented in 20 doses liquid presentation with phenol as preservative, which has considerable advantages in developing country immunization programmes, especially in campaign settings, as they are economical, occupy less space in the cold chain, and in many settings are preferable from the administration view point as well. However, in this case, these potential advantages could diminish through potential wastage. The vial contains 20 doses which makes it prone to such wastage. Therefore, this makes the vaccine more suitable for campaign settings, and users must weigh the significance of potentially high wastage in the context of routine vaccination programmes.

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Last update:

24 May 2013 16:08 CEST