International Programme on Chemical Safety

Dermal Absorption (EHC 235)

Dermal (percutaneous, skin) absorption is a global term that describes the transport of chemicals from the outer surface of the skin both into the skin and into the systemic circulation. Dermal absorption can occur from occupational, environmental, or consumer skin exposure to chemicals, cosmetics, and pharmaceutical products. This Environmental Health Criteria document presents an overview of dermal absorption and its consideration in the risk assessment of chemicals. It describes the methods available to assess dermal absorption, the significance of skin as a route of exposure and the interpretation of results of dermal absorption studies for risk assessment. In addition, it presents and discusses current topics of interest in the field of dermal absorption.

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