Assessment of combined exposures to multiple chemicals
Regulators and other risk assessors need to estimate the combined risks arising from real-life exposure to multiple chemical agents and repeated exposures.
In March 2007, IPCS convened an international workshop on current issues in aggregate/cumulative risk assessment.
A draft WHO/IPCS Framework for Risk Assessment of Combined Exposures to Multiple Chemicals was released for public comment in 2009, together with two case studies. The Framework and additional case studies were further developed during 2010 and subsequently published as: M.E. (Bette) Meek, Alan R. Boobis, Kevin M. Crofton, Gerhard Heinemeyer, Marcel Van Raaij, Carolyn Vickers (2011)
- Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework. Regulatory Toxicology and Pharmacology
Following publication of the WHO Framework, an international workshop was convened to identify needs for further work on combined exposures. The report of the workshop is published in: OECD (2011). WHO OECD ILSI/HESI International Workshop on Risk Assessment of Combined Exposures to Multiple Chemicals, Series on Testing and Assessment No. 140, ENV/JM/MONO(2011)10. OECD, Paris.