International Programme on Chemical Safety

Skin sensitization risk assessment

This Harmonization Project activity focused on skin sensitization in chemical risk assessment. An IPCS international workshop was convened from 17-18 October 2006, in Berlin, Germany with the aim of evaluating experimental techniques for their ability to produce data to inform risk assessment, including provision of dose-response information and information relating to sensitive sub-populations. The workshop focused on whether it is possible to distinguish between chemicals with a high potency to elicit allergic skin reactions and those with a low potency. Emerging approaches, such as Structure Activity Relationships (SAR) were explored. The meeting also explored whether assessment approaches for skin sensitization could inform approaches for the respiratory tract.