International Programme on Chemical Safety

Corrigendum

IPCS Environmental Health Criteria 71: Pentachlorophenol

Please note that these corrigenda have been incorporated in the electronic versions of the document.

Page 17, line 36 and page 168, line 42:
Since the publication of this monograph in 1987, however, the results of adequate carcinogenicity studies with commercial-grade pentachlorophenol have been published. The conclusions of these studies are indicated in the addendum to page 149.

Page 149, line 9:
The results of these studies have now been published (US NTP (1989) Toxicology and carcinogenesis studies of two pentachlorophenol technical-grade mixtures (CAS No. 87-86-5) in B6C3F1 mice (feed studies), Research Triangle Park, North Carolina, US National Toxicology Program, Technical Report No. 349, p. 98).  The conclusions were as follows:

"Under the conditions of these 2-year feed studies, there was clear evidence of carcinogenic activity for male B6C3F1 mice fed diets containing technical-grade pentachlorophenol, as shown by increased incidences of adrenal medullary and hepatocellular neoplasms. There was some evidence of carcinogenic activity for female B6C3F1 mice exposed to technical-grade pentachlorophenol, as shown by increased incidences of hemangiosarcomas and hepatocellular neoplasms.  There was clear evidence of carcinogenic activity for male B6C3F1 mice exposed to pentachlorophenol, EC-7, as shown by increased incidences of adrenal medullary and hepatocellular neoplasms.  There was clear evidence of carcinogenic activity for female B6C3F1 mice exposed to pentachlorophenol, EC-7, as shown by increased incidences of adrenal medullary and hepatocellular neoplasms and hemangiosarcomas."

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