Corrigendum
IPCS Environmental Health Criteria 71: Pentachlorophenol
Please note that these corrigenda have been incorporated in the electronic versions of the document.
Page 17, line 36 and page 168, line 42:
Since the publication of this monograph in 1987, however, the results of adequate carcinogenicity studies with commercial-grade pentachlorophenol have been published. The conclusions of these studies are indicated in the addendum to page 149.
Page 149, line 9:
The results of these studies have now been
published (US NTP (1989) Toxicology and carcinogenesis studies of two
pentachlorophenol technical-grade mixtures (CAS No. 87-86-5) in B6C3F1
mice (feed studies), Research Triangle Park, North Carolina, US National
Toxicology Program, Technical Report No. 349, p. 98). The conclusions were
as follows:
"Under the conditions of these 2-year feed
studies, there was clear evidence of carcinogenic activity for male B6C3F1
mice fed diets containing technical-grade pentachlorophenol, as shown by
increased incidences of adrenal medullary and hepatocellular neoplasms. There
was some evidence of carcinogenic activity for female B6C3F1 mice
exposed to technical-grade pentachlorophenol, as shown by increased incidences
of hemangiosarcomas and hepatocellular neoplasms. There was clear
evidence of carcinogenic activity for male B6C3F1 mice exposed to
pentachlorophenol, EC-7, as shown by increased incidences of adrenal medullary
and hepatocellular neoplasms. There was clear evidence of carcinogenic
activity for female B6C3F1 mice exposed to pentachlorophenol,
EC-7, as shown by increased incidences of adrenal medullary and hepatocellular
neoplasms and hemangiosarcomas."