Since 2006, two HPV vaccines have been licensed; one vaccine targets four and the other two HPV genotypes. Both vaccines are designed to protect against about 70% of cervical cancer cases worldwide (the 4-valent vaccine also protects against genital warts). Both vaccines are intended to be administered to females before the onset of sexual activity – that is, before first exposure to HPV infection. Most countries that have licensed these vaccines, recommend their use in girls aged 10–14 years. In some countries the quadrivalent vaccine is offered to girls as young as 9 years. Some national programmes also recommend routine - or temporary catchup vaccination - of older adolescent females and young women.
The complete series of quadrivalent vaccine is administered at day 0; 2 months; and 6 months. The bivalent vaccine is administered at day 0; 1 month; and 6 months. Repeating previous doses is not necessary if the 3-dose programme has been interrupted. Booster doses are currently not recommended.