Leprosy elimination

MDT and drug resistance

Is the threat of rifampicin-resistant leprosy a serious problem?

There are a few isolated reports of rifampicin-resistant leprosy; these are mainly from areas where rifampicin was given as monotherapy, either alone or in combination with dapsone, to dapsone-resistant patients. At the moment, the problem of rifampicin-resistant leprosy is not a serious one; however, selective non-compliance with dapsone and/or clofazimine by patients may facilitate the selection of rifampicin-resistant strains.