Request for proposals: Determining mutations in dihydrofolate reductase and dihydropteroate synthase genes for sulfadoxine-pyrimethamine resistance
WHO has published a Request for Proposals (RFP) for determining mutations in dihydrofolate reductase (dhfr) and dihydropteroate synthase genes (dhps) for sulfadoxine-pyrimethamine (SP) resistance as part of the TIPTOP project (Transforming Intermittent Preventive Treatment for Optimal Pregnancy).
Data collected on SP resistance will be used to inform future WHO policy reviews for IPTp with SP, and the experiences will be used to refine a protocol for monitoring efficacy of IPTp with SP. If a rapid increase in drug resistance to SP is found, this may mean that WHO will have to alter the recommendations on drug used in IPTp. If no significant increase in SP resistance is found, this will help ensure greater uptake of policy recommendation on IPTp with SP.
Intentions to bid should be submitted no later than 30 March 2018 and proposals no later than 20 April 2018.
The bidding process and all related correspondence must be conducted through the United Nations Global Marketplace (UNGM). Interested parties will therefore need to register with the UNGM at Basic level to access tender documents, submit questions, see answers given by WHO, and submit an intention to bid and a proposal.