Guidelines for the treatment of malaria. Second edition (archived)

March 2010


World Health Organization

Cover image

Publication details

Number of pages: 194
Publication date: 2010
Languages: English
ISBN: 9789241547925


Note: This edition of the guidelines is superseded by the third edition, published 22 April 2015. Please note that the second edition will no longer be available on this website by the end of May.


The World Health Organization's Guidelines for the treatment of malaria. Second edition provides evidence-based and up-to-date recommendations for countries on malaria diagnosis and treatment which help countries formulate their policies and strategies.

In scope, the Guidelines cover the diagnosis and treatment of uncomplicated and severe malaria caused by all types of malaria, including in special groups (such as young children, pregnant women and HIV/AIDS patients), in travellers (from non-malaria endemic regions) and in epidemics and complex emergency situations.

The first edition of the Guidelines for the treatment of malaria was published in 2006. The second edition introduces a new fifth ACT to the four already recommended for the treatment of uncomplicated malaria. Furthermore, the Guidelines recommend a parasitological confirmation of diagnosis in all patients suspected of having malaria before treatment.

The move towards universal diagnostic testing of malaria is a critical step forward in the fight against malaria as it will allow for the targeted use of ACTs for those who actually have malaria. This will help to reduce the emergence and spread of drug resistance. It will also help identify patients who do not have malaria, so that alternative diagnoses can be made and appropriate treatment provided. The new Guidelines will therefore help improve the management of not only malaria, but other childhood febrile illnesses.