Conditions for deployment of mosquito nets treated with a pyrethroid and piperonyl butoxide
Mosquito nets that include both a pyrethroid insecticide and the synergist piperonyl butoxide (PBO) have become available. Five of these nets were recently evaluated under the WHO Pesticide Evaluation Scheme (WHOPES) to determine whether they met the criteria established for classification as a pyrethroid-treated long-lasting insecticidal net (LLIN).
In the ongoing transition of the WHO evaluation process for vector control products from WHOPES to the Prequalification Team, WHO has updated its policy recommendations on the deployment of pyrethroid-PBO nets. This update is an attempt to further clarify the available evidence base for these types of nets, their categorization under the revised evaluation system, and the additional data required to support WHO’s policy-making process.
This represents an exception to the standard review procedure, which requires a minimum of two epidemiological trials to assess the public health value of new vector control tools not covered by an existing policy. It also presents an exception to standard procedures in that the data supporting the revised recommendations were reviewed prior to having been published in the peer reviewed literature.
These recommendations replace the 2015 WHO recommendations on pyrethroid-PBO nets and will be further revised as new data become available, or may require modification if the published data differ from those initially reviewed by the WHO Evidence Review Group and the Malaria Policy Advisory Committee (MPAC).