Antidepressants (Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors) in children 6-12 years of age with depressive episode/disorder
Question 10: Are antidepressants (Tricyclic antidepressants (TCA), Selective serotonin reuptake inhibitors (SSRI)) effective and safe in children 6-12 years of age with depressive episode/disorder?
- Population: children (6-12 years) with depressive episode/disorder
- Interventions: antidepressant drugs:
- tricyclics and related
- selective serotonin reuptake inhibitors
- Comparison: placebo
- Outcomes:
- symptom reduction
- overall performance at school
- family functioning
- adverse effects of treatment
- improvement in physical health
- user and family satisfaction
- reduction in risk behaviour.
Recommendation(s)
Antidepressants (Tricyclic antidepressants (TCA), Selective serotonin reuptake inhibitors (SSRI)) should not be used for the treatment of children 6-12 years of age with depressive episode/disorder in non-specialist settings.
Strength of recommendation: STRONG