Post-exposure treatment of previously vaccinated persons

Local treatment of wounds should always be carried out. On the basis of the information available at the time, the eighth report of the WHO Expert Committee recommended that persons who had previously received full pre- or post-exposure treatment with a potent cell-culture vaccine should be given only two booster doses, either intramuscularly or intradermally, on days 0 and 3, but no rabies immunoglobulin. Persons who have previously received pre- or post-exposure treatment with vaccines of unproven potency, and those who have not demonstrated an acceptable rabies neutralizing antibody titre, should receive a complete post-exposure course, including rabies immunoglobulin if indicated.