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  WHO > Programmes and projects > Tuberculosis (TB) > Address TB/HIV, MDR/XDR-TB and other challenges > Drug- and multidrug-resistant tuberculosis (MDR-TB)

Drug- and multidrug-resistant tuberculosis (MDR-TB)

XDR-TB
Extensively drug-resistant tuberculosis

The challenge
Anti-tuberculosis (TB) drug resistance is a major public health problem that threatens the success of DOTS, the WHO-recommended treatment approach for detection and cure of TB, as well as global tuberculosis control.
What is DOTS?

How does drug-susceptible TB become drug-resistant TB?
Drug resistance arises due to the improper use of antibiotics in chemotherapy of drug-susceptible TB patients. This improper use is a result of a number of actions, including administration of improper treatment regimens by health-care workers and failure to ensure that patients complete the whole course of treatment. Essentially, drug resistance arises in areas with poor TB control programmes.
Questions about drug-resistant TB

Ministerial meeting of high M/XDR-TB burden countries
Ministers from high M/XDR-TB burden countries met in Beijing, China, during 1-3 April 2009, to urgently address the alarming threat of MDR-TB.
More about the ministerial meeting

Key bottlenecks in M/XDR-TB control and patient care
A major point of discussion at the ministerial meeting in Beijing will be a number of key bottlenecks, which are common across many affected countries planning and beginning to implement the M/XDR-TB response, requiring political decisions within the health system as a whole to overcome.
Key bottlenecks in M/XDR-TB control and patient care

Management of multidrug resistance

- The Green Light Committee (GLC)

Surveillance of drug resistance in TB

- The Global Project on Anti-Tuberculosis Drug Resistance Surveillance
- Resources: publications/documents/software

:: Strengthening tuberculosis laboratories
:: Other WHO sites on drug resistance
:: MDR-TB working group (Stop TB Partnership)

The Stop TB Partnership logo
A partnership
housed by WHO


HIGHLIGHTED DOCUMENTS

Guidelines for surveillance of drug resistance in tuberculosis - 4th edition
Guidelines for surveillance of drug resistance in tuberculosis

Download the guidelines

Guidelines for the programmatic management of drug-resistant tuberculosis: Emergency update 2008
Guidelines for the programmatic management of drug-resistant tuberculosis

Emergency update 2008

Download the guidelines

Global Tuberculosis Control Report 2009 - book cover
Global TB Control Report
Read online or download the report

Anti-tuberculosis drug resistance in the world.  Report no. 4
Anti-tuberculosis drug resistance in the world. Fourth global report
Read the report

Stop TB Strategy book cover
The Stop TB Strategy
Full text


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