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  • Diseases & topics

African trypanosomiasis

Human African trypanosomiasis or sleeping sickness is a widespread tropical disease that can be fatal if not treated. It is spread by the bite of an infected tsetse fly (Glossina Genus).

The tsetse fly bite erupts into a red sore and within a few weeks the person can experience fever, swollen lymph glands, aching muscles and joints, headaches and irritability.

In advanced stages, the disease attacks the central nervous system, causing changes in personality, alteration of the biological clock (the circadian rhythm), confusion, slurred speech, seizures, and difficulty walking and talking. These problems can develop over many years in the Gambiense form and some months in the Rhodesiense form; if not treated, the person will die.

Control of sleeping sickness is based on reduction of the reservoirs of infection by early diagnosis and control of tsetse flies.

TDR related research

TDR supports research on this disease. Our work is being conducted in the following areas:

  • Studies of pentamidine treatment for stage 1 of the disease (3 days instead of 7) and nifurtimox-eflornithine
  • Tsetse fly control methods and strategies

Latest news

  • A call for closer ties to communities
    5 March 2013
  • Pipeline grows for neglected diseases research and development (R&D)
    4 February 2013
  • Resolution on neglected tropical diseases to be recommended to WHO Health Assembly
    29 January 2013
  • All news on African trypanosomiasis

TDR publications and articles

  • Research Priorities for Chagas Disease, Human African Trypanosomiasis and Leishmaniasis
    Technical Report of the TDR Disease Reference Group on Chagas Disease, Human African Trypanosomiasis and Leishmaniasis
    27 November 2012
  • Changing Mindsets: Research Capacity strengthening in low and middle-income countries
    1 November 2010
  • A human rights-based approach to neglected tropical diseases
    20 February 2009
  • Strategic and business plan for the African Network for Drugs and Diagnostics Innovation (ANDI)
    Creating a sustainable platform for R&D innovation in Africa
    1 January 2009
  • All publications on African trypanosomiasis

Documentary

  • Survival — The Deadliest Disease
    A documentary (streaming) - Sleeping Sickness is the deadliest disease in the world. The Democratic Republic of Congo suffers more cases than any other country. Without treatment, parasites kill.

Disease transmission

  • Animated life-cycle of Trypanosoma brucei in the human host (Flash)
    swf, 265kb
  • Animated life-cycle of Trypanosoma brucei in the tsetse fly (Flash)
    swf, 275kb
  • Life-cycle of Trypanosoma brucei
    gif, 31kb

Related WHO information

  • Fact sheet: African trypanosomiasis or sleeping sickness
  • Publications: African trypanosomiasis
  • Symptoms, diagnosis & treatment
  • International travel and health
    Publication on travel risks, precautions and vaccination requirements

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