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  • Diseases & topics

Leishmaniasis

Leishmaniasis is caused by parasitic protozoa of the genus Leishmania. Humans are infected via the bite of phlebotomine sandflies, which breed in forest areas, caves and adobe brick houses where most of the transmission to humans takes place.

There are four main types of the disease:

  • In cutaneous forms, skin ulcers usually form on exposed areas, such as the face, arms and legs. These usually heal within a few months, leaving scars.
  • Diffuse cutaneous leishmaniasis produces disseminated and chronic skin lesions resembling those of lepromatous leprosy. It is difficult to treat.
  • In mucocutaneous forms, the lesions can partially or totally destroy the mucous membranes of the nose, mouth and throat cavities and surrounding tissues.
  • Visceral leishmaniasis, also known as kala azar, is characterized by high fever, substantial weight loss, swelling of the spleen and liver, and anaemia. If left untreated, the disease can have a fatality rate as high as 100% within two years.

TDR related research

TDR supports research on this disease. Our work is being conducted in the following areas:

  • Visceral leishmaniasis elimination

Latest news

  • Standards for cutaneous leishmaniasis clinical trials published
    Quality methods documented
    25 March 2013
  • A call for closer ties to communities
    5 March 2013
  • All news on leishmaniasis

Publication highlights

  • Visceral Leishmaniasis Rapid Diagnostic Test Performance
    Diagnostics Evaluation Series No. 4
    24 August 2011
  • Monitoring and evaluation tool kit for indoor residual spraying
    Kala-azar elimination in Bangladesh, India and Nepal
    21 October 2010
  • Indicators for monitoring and evaluation of the kala-azar elimination programme
    Kala-azar elimination in Bangladesh, India and Nepal
    21 October 2010
  • All publications on leishmaniasis

Leishmaniasis transmission

  • Animated life-cycle of Leishmania sp. in the human host
    swf, 280kb
  • Animated life-cycle of Leishmania sp. in the sandfly
    swf, 214kb

Related WHO information

  • Leishmaniasis: background information
  • Vaccine research
  • International travel and health
    Publication on travel risks, precautions and vaccination requirements

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