Workplan: Genomics and Discovery Research
Rationale
The Committee on Genomics and Discovery Research (GDR) is a component of the Steering Committee on Strategic and Discovery Research (SDR) in TDR. The fundamental goals of GDR are to support (1) the identification and validation of new molecular targets for drugs and diagnostics using the wealth of genomic information that is now available and (2) the discovery of new lead compounds that have the potential to be developed into drugs to treat diseases in the TDR portfolio.
TDR supports discovery of novel targets and drugs for African trypanosomiasis, malaria, leishmaniasis, filarial diseases, schistosomiasis and tuberculosis. TDR has actively supported, and continues to support, the efforts of international networks to determine and exploit the genome sequences of pathogens and their vectors. These data and new technologies in genomics provide opportunities for the development of novel interventions against diseases in the TDR portfolio. "Genomics" is now a starting point for the "discovery" of new drug and diagnostic targets which can be developed as practical and affordable tools for field use. The Committee on Genomics and Discovery Research is designed to support research activities that utilize genomic data in combination with novel molecular and/or chemical technologies for the identification, characterization and validation of targets and the discovery of lead inhibitors for drug development.
The Committee has a strong commitment to support research capability strengthening within projects with the aim of forging productive collaborations between laboratories in disease-endemic countries and laboratories in well-resourced countries.
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