TDR funded research in the scientific press 2009

Reference list

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(13) Angel B, Joshi V. Distribution of dengue virus types in Aedes aegypti in dengue endemic districts of Rajasthan, India. Indian J Med Res 2009; 129(6):665-668.
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(14) Antonio-Nkondjio C, Ndo C, Costantini C, Awono-Ambene P, Fontenille D, Simard F. Distribution and larval habitat characterization of Anopheles moucheti, Anopheles nili, and other malaria vectors in river networks of southern Cameroon. Acta Trop 2009; 112(3):270-276.
Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte Contre les Endemies en Afrique Centrale (OCEAC), P.O. Box 288, Yaounde, Cameroon. antonio nk@yahoo.fr. PubMed

(15) Awolola TS, Oduola OA, Strode C, Koekemoer LL, Brooke B, Ranson H. Evidence of multiple pyrethroid resistance mechanisms in the malaria vector Anopheles gambiae sensu stricto from Nigeria. Trans R Soc Trop Med Hyg 2009; 103(11):1139-1145.
Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria. awololas@hotmail.com. PubMed

(16) Ayub MJ, Atwood J, Nuccio A, Tarleton R, Levin MJ. Proteomic analysis of the Trypanosoma cruzi ribosomal proteins. Biochem Biophys Res Commun 2009; 382(1):30-34.
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(17) Barbu C, Dumonteil E, Gourbiere S. Optimization of control strategies for non-domiciliated Triatoma dimidiata, Chagas disease vector in the Yucatan Peninsula, Mexico. PLoS Negl Trop Dis 2009; 3(4):e416.
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Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. daniella@icb.ufmg.br. PubMed

(19) Baton LA, Robertson A, Warr E, Strand MR, Dimopoulos G. Genome-wide transcriptomic profiling of Anopheles gambiae hemocytes reveals pathogen-specific signatures upon bacterial challenge and Plasmodium berghei infection. BMC Genomics 2009; 10:257.
W. Harry Feinstone Department of Molecular Microbiology & Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205-2179, USA. lbaton@jhsph.edu. PubMed

(20) Bercovich N, Levin MJ, Clayton C, Vazquez MP. Identification of core components of the exon junction complex in trypanosomes. Mol Biochem Parasitol 2009; 166(2):190-193.
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(21) Bernhardt SA, Blair C, Sylla M, Bosio C, Black WC. Evidence of multiple chromosomal inversions in Aedes aegypti formosus from Senegal. Insect Mol Biol 2009; 18(5):557-569.
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA. PubMed

(22) Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC et al. The genome of the blood fluke Schistosoma mansoni. Nature 2009; 460(7253):352-358.
Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK. mb4@sanger.ac.uk. PubMed

(23) Black CL, Ocana-Mayorga S, Riner DK, Costales JA, Lascano MS, Arcos-Teran L et al. Seroprevalence of Trypanosoma cruzi in rural Ecuador and clustering of seropositivity within households. Am J Trop Med Hyg 2009; 81(6):1035-1040.
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(24) Bouteille B, Mpandzou G, Cespuglio R, Ngampo S, Peeling RW, Vincendeau P et al. Cerebrospinal fluid B lymphocyte identification for diagnosis and follow-up in human African trypanosomiasis in the field. Trop Med Int Health 2009.
Laboratory of Parasitology, EA 3174, Faculty of Medicine, University of Limoges, France. PubMed

(25) Brasseur P, Agnamey P, Gaye O, Cisse M, Badiane M, Vaillant M et al. Dosing accuracy of artesunate and amodiaquine as treatment for falciparum malaria in Casamance, Senegal. Trop Med Int Health 2009; 14(1):79-87.
Institut de Recherche pour le Developpement (IRD), Dakar, Senegal. PubMed

(26) Bukachi SA, Wandibba S, Nyamongo IK. The treatment pathways followed by cases of human African trypanosomiasis in western Kenya and eastern Uganda. Ann Trop Med Parasitol 2009; 103(3):211-220.
Institute of Anthropology, Gender and African Studies, University of Nairobi, P.O. Box, 30197-00100, Nairobi, Kenya. sallybukachi@yahoo.com. PubMed

(27) Burgos JM, Altcheh J, Petrucelli N, Bisio M, Levin MJ, Freilij H et al. Molecular diagnosis and treatment monitoring of congenital transmission of Trypanosoma cruzi to twins of a triplet delivery. Diagn Microbiol Infect Dis 2009; 65(1):58-61.
Laboratorio de Biologia Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI-CONICET), Buenos Aires C1428ADL, Argentina. PubMed

(28) Caprara A, Lima JW, Marinho AC, Calvasina PG, Landim LP, Sommerfeld J. Irregular water supply, household usage and dengue: a bio-social study in the Brazilian Northeast. Cad Saude Publica 2009; 25 Suppl 1:S125-S136.
Departamento de Saude Publica, Universidade Estadual do Ceara, Fortaleza, Brasil. caprara@uece.br. PubMed

(29) Castro-Gomes T, Almeida-Campos FR, Calzavara-Silva CE, da Silva RA, Frezard F, Horta MF. Membrane binding requirements for the cytolytic activity of Leishmania amazonensis leishporin. FEBS Lett 2009; 583(19):3209-3214.
Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil. PubMed

(30) Chuma J, Musimbi J, Okungu V, Goodman C, Molyneux C. Reducing user fees for primary health care in Kenya: Policy on paper or policy in practice? Int J Equity Health 2009; 8:15.
KEMRI/Wellcome Trust Programme, PO Box 230, Kilifi, Kenya. jchuma@kilifi.kemri-wellcome.org. PubMed

(31) Correa Soares JB, Menezes D, Vannier-Santos MA, Ferreira-Pereira A, Almeida GT, Venancio TM et al. Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols. PLoS Negl Trop Dis 2009; 3(7):e477.
Laboratorio de Bioquimica Redox, Programa de Biologia Molecular e Biotecnologia, Instituto de Bioquimica Medica, Universidade Federal do Rio de janeiro, Rio de Janeiro, Brazil. PubMed

(32) Costa GC, da Costa Rocha MO, Moreira PR, Menezes CA, Silva MR, Gollob KJ et al. Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy. J Infect Dis 2009; 199(3):451-454.
Laboratory of Cell-Cell Interactions, Department of Morphology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil. PubMed

(33) Crowther GJ, Napuli AJ, Thomas AP, Chung DJ, Kovzun KV, Leibly DJ et al. Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. J Biomol Screen 2009; 14(6):700-707.
Department of Medicine, University of Washington, Seattle, WA 98195-7185, USA. crowther@u.washington.edu. PubMed

(34) Crowther GJ, He P, Rodenbough PP, Thomas AP, Kovzun KV, Leibly DJ et al. Use of thermal melt curves to assess the quality of enzyme preparations. Anal Biochem 2009.
Department of Medicine, University of Washington, Seattle, WA 98195, USA. PubMed

(35) Cruz AK, de Toledo JS, Falade M, Terrao MC, Kamchonwongpaisan S, Kyle DE et al. Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review. Curr Drug Targets 2009; 10(3):178-192.
Departamento de Biologia Celular e Molecular e Bioagentes Patogenicos, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil. akcruz@fmrp.usp.br. PubMed

(36) Dabire KR, Diabate A, Namontougou M, Djogbenou L, Kengne P, Simard F et al. Distribution of insensitive acetylcholinesterase (ace-1R) in Anopheles gambiae s.l. populations from Burkina Faso (West Africa). Trop Med Int Health 2009; 14(4):396-403.
Institut de Recherche en Sciences de la Sante/Centre Muraz, Bobo-Dioulasso, Burkina Faso. dabire_roch@hotmail.com. PubMed

(37) Dabire KR, Diabate A, Namountougou M, Toe KH, Ouari A, Kengne P et al. Distribution of pyrethroid and DDT resistance and the L1014F kdr mutation in Anopheles gambiae s.l. from Burkina Faso (West Africa). Trans R Soc Trop Med Hyg 2009; 103(11):1113-1120.
Insitut de Recherche en Science de la Sante (IRSS)/Centre Muraz, BP 390, Bobo-Dioulasso, Burkina Faso. dabire_roch@hotmail.com. PubMed

(38) Dar A, Prusty D, Mondal N, Dhar SK. A unique 45-amino-acid region in the toprim domain of Plasmodium falciparum gyrase B is essential for its activity. Eukaryot Cell 2009; 8(11):1759-1769.
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India. PubMed

(39) Das ML, Roy L, Rijal S, Paudel IS, Picado A, Kroeger A et al. Comparative study of kala-azar vector control measures in eastern Nepal. Acta Trop 2009.
Department of Microbiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal. PubMed

(40) Diawara L, Traore MO, Badji A, Bissan Y, Doumbia K, Goita SF et al. Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal. PLoS Negl Trop Dis 2009; 3(7):e497.
Ministere de Sante et de Prevention Medicale, Dakar, Senegal. PubMed

(41) Dodoo AN, Fogg C, Asiimwe A, Nartey ET, Kodua A, Tenkorang O et al. Pattern of drug utilization for treatment of uncomplicated malaria in urban Ghana following national treatment policy change to artemisinin-combination therapy. Malar J 2009; 8:2.
Centre for Tropical Clinical Pharmacology & Therapeutics, University of Ghana Medical School, P,O, Box KB 4236, Accra, Ghana. alexooo@yahoo.com. PubMed

(42) Dong Y, Dimopoulos G. Anopheles fibrinogen-related proteins provide expanded pattern recognition capacity against bacteria and malaria parasites. J Biol Chem 2009; 284(15):9835-9844.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA. PubMed

(43) Dong Y, Manfredini F, Dimopoulos G. Implication of the mosquito midgut microbiota in the defense against malaria parasites. PLoS Pathog 2009; 5(5):e1000423.
W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America. PubMed

(44) Dorn PL, Calderon C, Melgar S, Moguel B, Solorzano E, Dumonteil E et al. Two distinct Triatoma dimidiata (Latreille, 1811) taxa are found in sympatry in Guatemala and Mexico. PLoS Negl Trop Dis 2009; 3(3):e393.
Loyola University New Orleans, New Orleans, Louisiana, USA. dorn@loyno.edu. PubMed

(45) Duffy T, Bisio M, Altcheh J, Burgos JM, Diez M, Levin MJ et al. Accurate real-time PCR strategy for monitoring bloodstream parasitic loads in chagas disease patients. PLoS Negl Trop Dis 2009; 3(4):e419.
Laboratorio de Biologia Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI-CONICET), Buenos Aires, Argentina. PubMed

(46) Dutra WO, Moreira PR, Souza PE, Gollob KJ, Gomez RS. Implications of cytokine gene polymorphisms on the orchestration of the immune response: lessons learned from oral diseases. Cytokine Growth Factor Rev 2009; 20(3):223-232.
Laboratory of Cell-Cell Interactions, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, CEP 31270-901, Belo Horizonte-MG, Brazil. waldutra@gmail.com. PubMed

(47) Dutra WO, Menezes CA, Villani FN, da Costa GC, da Silveira AB, Reis D et al. Cellular and genetic mechanisms involved in the generation of protective and pathogenic immune responses in human Chagas disease. Mem Inst Oswaldo Cruz 2009; 104 Suppl 1:208-218.
Departamento de Morfologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. waldutra@gmail.com. PubMed

(48) Eberle C, Burkhard JA, Stump B, Kaiser M, Brun R, Krauth-Siegel RL et al. Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds. ChemMedChem 2009; 4(12):2034-2044.
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(49) Elmardi KA, Malik EM, Abdelgadir T, Ali SH, Elsyed AH, Mudather MA et al. Feasibility and acceptability of home-based management of malaria strategy adapted to Sudan's conditions using artemisinin-based combination therapy and rapid diagnostic test. Malar J 2009; 8:39.
National Malaria Control Programme, Federal Ministry of Health, Khartoum, Sudan. khalidmrd9@hotmail.com. PubMed

(50) Elsanousi S, Abdelrahman S, Elshiekh I, Elhadi M, Mohamadani A, Habour A et al. A study of the use and impacts of LifeStraw in a settlement camp in southern Gezira, Sudan. J Water Health 2009; 7(3):478-483.
Department of Community Medicine, Faculty of Medicine, University of Gezira, WadMedani, Sudan. PubMed

(51) Etang J, Vicente JL, Nwane P, Chouaibou M, Morlais I, Do Rosario VE et al. Polymorphism of intron-1 in the voltage-gated sodium channel gene of Anopheles gambiae s.s. populations from Cameroon with emphasis on insecticide knockdown resistance mutations. Mol Ecol 2009; 18(14):3076-3086.
Organisation de Coordination Pour Lutte Contre Endemies en Afrique Centrale, PO Box 288, Yaounde, Cameroon. josyet@yahoo.fr. PubMed

(52) Gansane A, Sanon S, Ouattara LP, Traore A, Hutter S, Ollivier E et al. Antiplasmodial activity and toxicity of crude extracts from alternatives parts of plants widely used for the treatment of malaria in Burkina Faso: contribution for their preservation. Parasitol Res 2009.
Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, 01 POB 2208, Ouagadougou 01, Burkina Faso. PubMed

(53) Garcia AL, Parrado R, Rojas E, Delgado R, Dujardin JC, Reithinger R. Leishmaniases in Bolivia: comprehensive review and current status. Am J Trop Med Hyg 2009; 80(5):704-711.
CUMETROP, Universidad Mayor de San Simon, Cochabamba, Bolivia. PubMed

(54) Garver LS, Dong Y, Dimopoulos G. Caspar controls resistance to Plasmodium falciparum in diverse anopheline species. PLoS Pathog 2009; 5(3):e1000335.
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America. PubMed

(55) Gaudin K, Millet P, Fawaz F, Olliaro P, White NJ, Cassus-Coussere C et al. Investigation of porous graphitic carbon at high-temperature liquid chromatography with evaporative light scattering detection for the analysis of the drug combination artesunate-Azithromycin for the treatment of severe malaria. J Chromatogr A 2009.
PPF-Medicament-Parasitologie, Laboratoire de Chimie Analytique, Universite Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France. PubMed

(56) Gbotosho GO, Happi CT, Sijuade AO, Sowunmi A, Oduola AM. A simple cost-effective high performance liquid chromatographic assay of sulphadoxine in whole blood spotted on filter paper for field studies. Malar J 2009; 8:238.
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria. solagbotosho@yahoo.co.uk. PubMed

(57) Gbotosho GO, Happi CT, Sijuade A, Sowunmi A, Oduola A. Pharmacokinetic Disposition of Sulfadoxine in Children with Acute Uncomplicated Falciparum Malaria Treated with Sulfadoxine-Pyrimethamine in South West Nigeria. Am J Ther 2009.
1Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria; 2Malaria Research Laboratories, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria; and 3WHO/TDR, Geneva, Switzerland. PubMed

(58) Gemma S, Campiani G, Butini S, Joshi BP, Kukreja G, Coccone SS et al. Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. J Med Chem 2009; 52(2):502-513.
European Research Centre for Drug Discovery and Development and Dipartimento Farmaco Chimico Tecnologico, Universita di Siena, Via Aldo Moro, 53100 Siena, Italy. PubMed

(59) Gicheru MM, Jeneby MM, Macharia JC, Carlsson HE, Suleman MA. Prevalence of antibodies and cell mediated immune response against Leishmania major in feral nonhuman primates from Kenya. Acta Trop 2009; 109(2):136-140.
Institute of Primate Research, National Museums of Kenya, Karen, Nairobi, Kenya. PubMed

(60) Gigante F, Kaiser M, Brun R, Gilbert IH. SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents. Bioorg Med Chem 2009; 17(16):5950-5961.
University of Dundee, Sir James Black Centre, UK. PubMed

(61) Gobert GN, McManus DP, Nawaratna S, Moertel L, Mulvenna J, Jones MK. Tissue specific profiling of females of Schistosoma japonicum by integrated laser microdissection microscopy and microarray analysis. PLoS Negl Trop Dis 2009; 3(6):e469.
Queensland Institute of Medical Research, Herston, Queensland, Australia. PubMed

(62) Gomes MF, Faiz MA, Gyapong JO, Warsame M, Agbenyega T, Babiker A et al. Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet 2009; 373(9663):557-566.
UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland. gomesm@who.int. PubMed

(63) Goncalves RL, Machado AC, Paiva-Silva GO, Sorgine MH, Momoli MM, Oliveira JH et al. Blood-feeding induces reversible functional changes in flight muscle mitochondria of Aedes aegypti mosquito. PLoS One 2009; 4(11):e7854.
Laboratorio de Bioquimica Redox, Instituto de Bioquimica Medica, Programa de Biologia Molecular e Biotecnologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. PubMed

(64) Grijalva MJ, Villacis AG. Presence of Rhodnius ecuadoriensis in sylvatic habitats in the southern highlands (Loja Province) of Ecuador. J Med Entomol 2009; 46(3):708-711.
Tropical Disease Institute, Biomedical Sciences Department, College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA. grijalva@ohiou.edu. PubMed

(65) Guelbeogo WM, Sagnon N, Grushko O, Yameogo MA, Boccolini D, Besansky NJ et al. Seasonal distribution of Anopheles funestus chromosomal forms from Burkina Faso. Malar J 2009; 8:239.
Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso. guelbeogo.cnrfp@fasonet.bf. PubMed

(66) Guimaraes-Costa AB, Nascimento MT, Froment GS, Soares RP, Morgado FN, Conceicao-Silva F et al. Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps. Proc Natl Acad Sci U S A 2009; 106(16):6748-6753.
Departamento de Imunologia, Instituto de Microbiologia Prof. Paulo de Goes, Universidade Federal do Rio de Janeiro, Bloco I, 21941-902, Rio de Janeiro, Brazil. PubMed

(67) Happi CT, Gbotosho GO, Folarin OA, Sowunmi A, Hudson T, O'Neil M et al. Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria. Antimicrob Agents Chemother 2009; 53(3):888-895.
Malaria Research Laboratories, IMRAT, College of Medicine, University of Ibadan, Ibadan, Nigeria. chappi@hsph.harvard.edu. PubMed

(68) Hasan Z, Jamil B, Ashraf M, Islam M, Dojki M, Irfan M et al. Differential live Mycobacterium tuberculosis-, M. bovis BCG-, recombinant ESAT6-, and culture filtrate protein 10-induced immunity in tuberculosis. Clin Vaccine Immunol 2009; 16(7):991-998.
Department of Pathology and Microbiology, Aga Khan University, Karachi, Pakistan. zahra.hasan@aku.edu. PubMed

(69) Hasan Z, Jamil B, Khan J, Ali R, Khan MA, Nasir N et al. Relationship between circulating levels of IFN-gamma, IL-10, CXCL9 and CCL2 in pulmonary and extrapulmonary tuberculosis is dependent on disease severity. Scand J Immunol 2009; 69(3):259-267.
Department of Pathology and Microbiology, The Aga Khan University, Karachi, Pakistan. zahra.hasan@aku.edu. PubMed

(70) Hasan Z, Jamil B, Ashraf M, Islam M, Yusuf MS, Khan JA et al. ESAT6-induced IFNgamma and CXCL9 can differentiate severity of tuberculosis. PLoS One 2009; 4(4):e5158.
Department of Pathology and Microbiology, The Aga Khan University, Karachi, Pakistan. zahra.hasan@aku.edu. PubMed

(71) Hassan MM, Osman OF, El-Raba'a FM, Schallig HD, Elnaiem DE. Role of the domestic dog as a reservoir host of Leishmania donovani in eastern Sudan. Parasit Vectors 2009; 2(1):26.
Department of Epidemiology, Tropical Medicine Research Institute, National Centre for Research, Ministry of Science and Technology, PO Box 1304, Khartoum, Sudan. moawia65@hotmail.com. PubMed

(72) Heidler P, Zohrabi-Kalantari V, Kaiser M, Brun R, Emmrich T, Link A. Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine derivatives. Bioorg Med Chem 2009; 17(4):1428-1436.
Institute of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany. PubMed

(73) Helb D, Jones M, Story E, Boehme C, Wallace E, Ho K et al. Rapid detection of Mycobacterium tuberculosis and rifampin-resistance using on-demand, near patient technology. J Clin Microbiol 2009.
Department of Medicine, New Jersey Medical School - UMDNJ, Newark, NJ; Cepheid, Sunnyvale, CA; Foundation for Innovative New Diagnostics, Geneva, Switzerland; Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam; Montefiore Medical Center, Bronx, NY; Department of Pathology, New Jersey Medical School - UMDNJ, Newark, NJ; Makerere University - UMDNJ Research Collaboration, Kampala, Uganda; Department of Medicine, Makerere University School of Medicine, Kampala, Uganda. PubMed

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