RNA interference as a means of identifying drug targets for Filariasis
Report of a WHO/TDR Scientific Working Group
This report was prepared following the meeting of a Working Group organized by WHO/TDR to discuss and make recommendations on "RNA Interference as a Means of Identifying Drug Targets for Filariases". Two recent scientific advances, genome sequencing of the filarial nematodes and techniques for gene silencing (RNA interference), provide new opportunities for target identification. The Working Group prepared a practical strategy for identifying and validating targets, sets of criteria for prioritizing candidate drug targets, and a framework for their exploitation for drug discovery.