TB and HIV research

Despite declining tuberculosis (TB) cases and death rates, in 2010 there were still an estimated 8.8 million new cases of TB, of which 12-14% were people also infected with HIV. The proportion of TB cases co-infected with HIV is highest in the African region, which accounted for 82% of TB cases among people living with HIV. The five countries with the largest number of new TB cases were India, China, South Africa, Indonesia and Pakistan. China and India alone accounted for 38% of all TB cases globally, illustrating the enormous challenges borne by several low- and middle-income countries with insufficient resources and competing priorities. In the meantime, weak health systems and policies in these countries have been one of the key obstacles in achieving universal access to TB care. TDR has supported research in some of these low- and middle-income countries to identify efficient diagnosis and treatment options.

Specific objectives

  • Develop evidence to shorten and simplify the treatment of TB in HIV-infected and -uninfected TB patient populations
  • Develop evidence for timing and optimal management of HIV-infected TB patients
  • Develop evidence in support of scaling up access to TB diagnosis and treatment, particularly for the poor and marginalized populations;
  • Support research aimed at developing and utilizing positive synergies and interactions between TB control programmes and health systems strengthening to optimize service delivery in disease endemic countries

For additional information, contact Rony Zachariah.

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