 |
Enterotoxigenic escherichia coli (ETEC)
Disease burden. Among children aged <5 years in the developing world, the annual burden of diarrhoea is estimated to be 1.5 billion episodes, accounting for 3 million deaths. In community-based studies of children in these settings, enterotoxigenic Escherichia coli (ETEC) is the most frequently isolated enteropathogen, accounting for approximately 210 million diarrhoea episodes and approximately 380 000 deaths annually. Continue
Objectives
- Definition of human immune responses to ETEC antigen
- Development, standardization, and validation of immunological correlates of vaccine protection in human trials
- Definition of correlates of immunological correlates of protective immunity
- Development and clinicaltesting of new living and non-living candidates
-
Background
-
WHO Fact sheet [new window]
Links
-
International Vaccine Institute [new window]
-
CDC disease information [new window]
Key documents
-
Pathogenicity of an Enterotoxigenic Escherichia coli Hemolysin (hlyA) Mutant in Gnotobiotic Piglets
-
Enterotoxigenic Escherichia coli: An Overview [offsite pdf]
Meetings
- ETEC Technical Meeting, Montreux, Switzerland, 8-9 September 2003 (WHO Meeting)
- Diarrhoeal Diseases Steering Committee, Montreux, Switzerland, 10-11September 2003 (WHO Meeting)
Steering committee
- WHO Steering Committee on Diarrhoeal Diseases
Disease Focal Point/Contact
Dr Duncan Steele
Research on Bacterial Vaccines
|
|
