WHO Pesticide Evaluation Scheme (WHOPES)

Generic risk assessment model for indoor residual spraying of insecticides

Second Edition

WHO/Department of control of neglected tropical diseases

Publication details

Editors: Dr R. Yadav/WHOPES
Number of pages: v, 40 p.
Publication date: March 2018
Languages: English
ISBN: 978 92 4 151375 3
WHO reference number:



This document provides a generic model that can be used for risk assessment of exposure to insecticide products applied as indoor residual sprays. It aims to harmonize the risk assessment of such insecticides for public health use in order to generate comparable data for their registering and labelling by national regulatory authorities. The assessment considers both adults and children (all age groups) as well as people in the following specific categories:

  • those preparing the spray;
  • those applying the spray;
  • residents living in the treated houses;
  • residents who participate in preparing and applying insecticides.

The structure of this document follows that of A generic risk assessment model for insecticide treatment and subsequent use of mosquito nets (WHO, 2004). Because risk assessment is a constantly evolving process, guidance is also subject to change. Readers are therefore advised to consider any newer guidance published by WHO and other authoritative sources.