Lassa Fever Outbreak Toolbox
Updated | October 2024
Welcome to the Lassa Fever Outbreak Toolbox
Key reference documents
- Lassa fever health topic sheet (World Health Organization; 2018).
- Lassa fever fact sheet (World Health Organization; 2017).
- Lassa Fever overview (Word Health Organization office for Africa; 2022).
Case definitions
WHO suggested outbreak case definition
Any person with gradual onset of one or more of the following: malaise, fever, headache, sore throat, cough, nausea, vomiting, diarrhoea, myalgia (muscle pain), central chest pain or retrosternal pain, or hearing loss and:
a. History of contact with excreta or urine of rodents; OR
b. History of contact with a probable or confirmed Lassa fever case within a period of 21 days of onset of symptoms OR
c. Inexplicable bleeding/haemorrhaging
Any suspected case who died without collection of specimens for laboratory testing.
Any suspected case with laboratory confirmation (positive IgM antibody, PCR or virus isolation).
Any suspected or probable case with a negative laboratory result (showing no specific antibodies, RNA or specific detectable antigens).
Laboratory confirmation
- Disease Commodity Packages - Lassa fever (Geneva: World Health organization; 2018).
- How to safely collect blood samples by phlebotomy from patients suspected to be infected with Lassa fever (Geneva: World Health Organization; 2018).
- How to safely ship human blood samples from Lassa cases within a country by road, rail and sea (Geneva: World Health Organization; 2018).
Response tools and resources
- WHO Target Product Profile for Lassa virus Vaccine (World Health Organization; 2017).
Training
- Introduction to Lassa Fever (Geneva: World Health Organization; 2018).
Other resources
- Standard precautions for the prevention and control of infections: aide-memoire (Geneva: World Health Organisation; 2022).