Several Member States in the WHO European Region are moving towards becoming tobacco-free: a smoking prevalence of 5% or less. Emphasis, in particular, is on protecting younger generations from smoking initiation and other tobacco-related harm. Protecting children from tobacco in the Region is essential, not only because smoking initiation is a key component of an important public health crisis, but also because Member States are responsible for supporting various children’s rights. This report highlights ongoing and emerging tobacco-related issues that affect children in the Region and examines the regulatory frameworks, commitments and other tools that Member States should use to protect children from tobacco. This also includes more novel approaches that could – and should – be used to pave the way towards a tobacco-free European Region.