On 1 February 2016, the WHO Director-General declared that recent clusters of cases of microcephaly and neurological disorders associated with Zika virus disease constitute a public health emergency of international concern under the International Health Regulations (2005). In light of the current widespread outbreak occurring in Latin America and the Caribbean, the risk for Zika virus importation and spread in the European Region should not be underestimated. To support countries in the European Region in targeting preparedness work and to guide prioritization of activities, the risk for a Zika virus disease outbreak was assessed.