In November 2023, the World Health Organization (WHO)’s Global Tuberculosis Programme (GTB) published the “Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance, second edition” (TB Mutation Catalogue). The catalogue provides a standardised interpretation of genome sequencing results that can be used by TB laboratories and test developers.
Updating the TB Mutation Catalogue:
WHO is continuing the process of updating the TB Mutation Catalogue with a primary focus to collect TB genotypic and phenotypic data sets with known resistance or susceptibility to the new and repurposed TB therapeutics: bedaquiline, linezolid, and delamanid. With the recent release of critical concentrations for phenotypic drug susceptibility testing, genotypic and phenotypic data sets for pretomanid and D-cycloserine will be also considered. Large collections from countries and regions not well represented in the current edition of the TB Mutation Catalogue will also be a focus of the effort. The work is being carried out in collaboration with FIND as part of the Unitaid-funded Seq&Treat project and all data contributions will be made to WHO/GTB.
Be a Part of the Solution – Donate Data:
If you’re interested in joining this global effort to improve drug resistant TB diagnosis, please consider providing genomic and phenotypic data for the third edition of the TB Mutation Catalogue through the WHO TB sequencing portal. Registration will be provided via a WHO guest authentication, that can be requested at tbsequencing@who.int. Once registered, users gain access to the data submission module at https://tbsequencing.who.int/data-submission where the WHO tabular templates for binary R/S or MIC phenotypic drug susceptibility testing results submission can be downloaded. Users will have the option to directly upload sequencing data or link the tabular data to submissions available at the International Nucleotide Sequence Database Collaboration.
Please submit data before 15th October 2024 to ensure your data will be included in the analysis for the third edition of the catalogue.
For further information, please contact Carl-Michael Nathanson at the WHO Global TB Programme, nathansonc@who.int or reach out to tbsequencing@who.int.