WHO consultation on COVID-19 vaccines research - Advancing the development of pan-sarbecovirus vaccines

In continuation to the scientific discussions on COVID-19 vaccines research, WHO R&D Blueprint organized a consultation to identify vaccine research priorities to facilitate further contributions of vaccines to achieve improved control of the pandemic everywhere.

This was scheduled on Friday, 25 March 2022 from 13h00 to 18h30 Geneva time (CET).

During this forthcoming consultation global experts reviewed the available evidence, enumerate knowledge gaps, and outlined research priorities related to pan-sarbecovirus vaccines. The objectives of the meeting were to:

• Review scientific advances and development approaches to enable the development of a pan-sarbecovirus vaccine.

• Outline novel approaches for evaluation of pan-sarbecovirus vaccines, including in the context of the different variants of concern.

• Discuss how we can prospectively evaluate vaccines intended to protect against viruses that are not yet circulating.

PRESENTATIONS

• Objectives of the meeting: We Need a ​PAN-SARBECOVIRUS​ Vaccine

State of the art for pan-sarbecovirus vaccines Session 1.

• Major challenges with the development of pan-coronavirus vaccines  
• Clinical Epidemiology of SARS-1, MERS, Respiratory Coronavirus
• Evolution of SARS-2 
• Geographic and Host distribution of Coronaviruses
• Clinical characteristics of Coronaviruses infections
• Pan‐sarbecovirus booster vaccination
• Strategies For A Pancoronavirus Vaccine
• SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine
  
• Development of pan-sarbecovirus vaccines 
• Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models
• Design and immunogenicity of a pan Sarbecovirus Dendritic-Cell targeting vaccine
• Framework for vaccine evaluation
• Towards a Pan-Sarbecovirus Vaccine: Progress and Anticipated Challenges
• Need for a pan-sarbecovirus vaccine? What are the challenges
• Variant-proof v pan-sarbecovirus vaccines
• Ongoing initiatives to support development of Broadly Protective Betacoronavirus Vaccines
• A forum for discussion on Sarbecovirus vaccines development ? What are the key issues to discuss next ?
• Overall conclusions and way forward

RECORDING