WHO operational handbook on tuberculosis: module 3: diagnosis

Overview

The “WHO operational handbook on tuberculosis. Module 3: diagnosis” provides an implementation guidance on detection of TB infection, disease and drug resistance within a single reference document. It also provides updates to the diagnostic algorithms, in view of new recommendations on concurrent testing of respiratory and non-respiratory samples among adults and adolescents with HIV, children with HIV, and children without HIV or with unknown HIV status. Finally, it summarizes updates on diagnostic accuracy of the WHO recommended technologies, in view of the WHO TB Diagnostic guidelines updates as well as analysis of discordant results.

This document accompanies the “WHO consolidated guidelines on tuberculosis. Module 3: diagnosis”, which summarizes and updates the latest WHO recommendations on the detection of TB infection, disease, and drug resistance for Member States, technical partners, and other stakeholders. 

The document includes several web annexes:

• Web Annex A. Information sheets;
• Web Annex B. Critical concentrations for pretomanid and cycloserine: systematic review and technical advisory group reports;
• Web Annex C. Technical manual for culture-based drug susceptibility testing of antituberculosis drugs used in the treatment of tuberculosis;
• Web Annex D. WHO TB interferon-gamma release assays and targeted next-generation sequencing solutions: systematic review and technical advisory group reports.