Fractional dose yellow fever vaccine as a dose-sparing option for outbreak response

Overview

This document is a summary of the World Health Organization (WHO) secretariat paper in response to the Yellow fever (YF) outbreak in Africa 2016, which has been discussed with YF experts and has been reviewed by WHO’s Strategic Advisory Group of Experts (SAGE) on Immunization. The development of this paper was led by the WHO Initiative for Vaccine Research gathering inputs to specific sections from the Pandemic and Epidemic diseases, Essential Medicines, and Immunization Vaccines and Biologicals departments of WHO. The Secretariat paper benefited from input by SAGE and the proposed recommendations were vetted by SAGE. This document will be further updated as additional data become available. A full review on the use of YF vaccine fractionate dose will be conducted by SAGE in October 2016.