WHO/BS/2020.2385 WHO 1st IS for Plasmodium Vivax antigens

Overview

An international collaborative study was conducted to assess the suitability of a candidate Plasmodium vivax preparation, assigned product code 19/116, for use as a World Health Organization (WHO) International Standard (IS) in the detection of P. vivax antigen lactate dehydrogenase (PvLDH). The potencies of the candidate IS and a range of P. vivax clinical isolates were evaluated using commercially available Enzyme-linked immunosorbent assays (ELISA) and a wide variety of malaria rapid diagnostic tests (RDT).