Evidence to Recommendation table: RTS,S/AS01 Malaria Vaccine, 2023

Overview

The Malaria Vaccine Implementation Programme (MVIP) was developed in response to the 2015 joint recommendation by SAGE and MPAC to introduce the RTS,S/AS01 (RTS,S) malaria vaccine in phased introductions in 3-5 African countries. Recognizing the potential of the vaccine to reduce clinical and severe malaria in African children, the pilots were designed to answer outstanding questions on safety, impact in routine use, and feasibility of reaching children with the recommended 4-dose schedule. The ministries of health (MoH) of the three pilot countries, Ghana, Kenya and Malawi, are delivering the RTS,S vaccine in selected areas through their child immunization services. Data are collected through the Malaria Vaccine Pilot Evaluation (MVPE) to inform WHO recommendations on the broader use of RTS,S in sub-Saharan Africa.