How long should young infants less than 2 months of age with moderate-mortality-risk signs of possible serious bacterial infection be hospitalized for?
14 April 2021
| Technical document
Overview
Among hospital-admitted young infants with any moderate-mortality risk sign [movement only when stimulated, or not feeding well or low body temperature (<35.5oC)] or two or more signs of clinical severe infection who clinically improve 48 hours after initiation of treatment and have a negative C-reactive protein (CRP) (Population), is discharged from hospital on oral amoxicillin at home for the next five days (Intervention), compared with continued hospital management for next five days (Control), non-inferior in terms of poor clinical outcome (death between randomization and day 15 of initiation of therapy, presence of any sign of CSI or CI on day 4, 8 of initiation of therapy) (Outcome)?
WHO Team
Child Health and Development (CHD),
Maternal, Newborn, Child & Adolescent Health & Ageing (MCA)
Editors
WHO
Number of pages
3