Requirements for human interferons prepared from lymphoblastoid cells, Annex 3, TRS No 786

Overview

The interferons (IFNs) are a family of protein initially thought to be of interest as inhibitors of virus growth. They are now known to have many other biological effects in vivo, including effects on cell growth and on many functions of the immune system. 

The requirements which follow take account of these points and should accordingly be met in the production control and testing of any human lymphoblastoid interferon preparation. These requirements have been formulated in relation to large-scale production, with particular reference to INF-a but, with appropriate changes, are likely to be applicable to preparations of INF-b or INF-y similarly derived from lymphoblastoid cells. 

Full version of the WHO Technical Report Series N° 786