Dengue
Dengue is a mosquito-borne infection that in recent decades has become a major international public health concern. Dengue is caused by four distinct, closely related, enveloped RNA viruses which are members of the flavivirus group. The dengue viruses, are the most widespread arthropod-borne viruses (arboviruses).
Dengue Vaccines
Dengue fever is a febrile illness that affects infants, young children and adults. Symptoms range from a mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash. More severe forms of the disease are dengue haemorrhagic fever (DHF) which is a potentially lethal complication with fever, abdominal pain, vomiting and bleeding which affects mainly children and dengue shock syndrome (DSS) where a very low blood pressure can cause organ dysfunction.
Dengue vaccine standardization
Written Standards
Guidelines on the quality, safety and efficacy of dengue tetravalent vaccines (live, attenuated) were adopted by ECBS in 2011.
- Guidelines on the quality, safety and efficacy of dengue tetravalent vaccines (live, attenuated). Annex 2, Technical Report Series No. 979. Replacement of Annex 1 of WHO Technical Report Series, No. 932
- Guidelines for the production and quality control of candidate tetravalent dengue virus vaccines (live). Annex 1, TRS No. 932, 2006
Reference materials
No WHO reference materials for dengue vaccines are currently available.
Publication

Meeting reports
Prequalified Dengue vaccines
There are no WHO pre-qualified vaccines against dengue.
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Further resources
WHO position paper on Dengue vaccination
Global dengue transmission map
Informing vaccination programs: a guide to the design and conduct of dengue serosurveys
Questions and answers on CYD dengue vaccine
Global Strategy for dengue prevention and control, 2012–2020
SAGE Working Group on Dengue Vaccines and Vaccination
Global Advisory Committe on Vaccine Safety - Dengue vaccines
Dengue: Guidelines for Diagnosis, Prevention, and Control
Handbook for clinical management of dengue
Special Programme for Research and Training in tropical diseases
International travel and health