The Second European Programme of Work (EPW2) is a five-year strategic framework (2026-2030) agreed by all Member States in the European Region to guide collective action towards a shared vision that all people live healthier, longer lives, with health safeguarded as a universal commitment. It builds on the first European Programme of Work, 2020–2025, and contributes to global health initiatives, including WHO’s Fourteenth General Programme of Work and the Sustainable Development Goals.