Results of Antimicrobial Resistance Surveillance in Uzbekistan, 2019–2022

Overview

The Proof-of-principle routine diagnostic project, conducted in Uzbekistan from 2019 to 2022, focused on enhancing antimicrobial resistance (‎AMR)‎ surveillance by improving microbiological diagnostics for bloodstream infections. Implemented across four health-care facilities and the National AMR Center, the project aimed to establish standardized BC sampling, strengthen antimicrobial susceptibility testing (‎AST)‎, and strengthen collaboration between clinical and laboratory teams. The study enrolled 2063 participants, identifying 299 positive cultures with significant pathogens such as Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. Resistance rates were high, with notable multidrug resistance in K. pneumoniae and methicillin resistance in S. aureus. The initiative successfully improved clinical workflows, trained health-care professionals, and contributed to the accreditation of the National AMR Center. Challenges included delays in AST turnaround times, procurement issues and adherence to sampling protocols. Recommended actions emphasize the need for expanding microbiological capacity, improving diagnostic timeliness, and sustaining national AMR surveillance to guide effective treatment policies and antimicrobial stewardship.