Noncommunicable diseases (NCDs) killed over 43 million people in 2021, equivalent to three-quarters of all non-pandemic-related deaths globally. About 18 million NCD deaths were among people younger than 70 years of age – more than all injuries, infections including COVID-19, and maternal and nutritional causes of death combined. 82% of these "premature" deaths occur in low- and middle-income countries. Cardiovascular diseases account for most NCD deaths, or over 19 million people annually, followed by cancers (10 million), chronic respiratory diseases (around 4 million), and diabetes (1.6 million).

In 2021, more than 700 000 people took their own life and there are many more people who attempt suicide. Suicide occurs throughout the lifespan and was the third leading cause of death among 15-29 year-olds globally in 2021. Suicide does not just occur in high-income countries, but is a global phenomenon in all regions of the world. In fact, about 73% of global suicides occurred in low- and middle-income countries in 2021.