Digital technologies and artificial intelligence (AI) are transforming how health systems deliver care, reach people, and respond to public health challenges across the WHO South-East Asia Region. Home to nearly two billion people across eleven Member States, roughly a quarter of the world's population, the Region confronts health workforce shortages, geographic remoteness, rising non-communicable disease burdens, climate-sensitive health risks, and persistent inequities in underserved communities, even as it hosts some of the world's most ambitious national digital health and AI programmes.