Blood transfusion is a life-saving intervention that has an essential role in patient management within the health-care system. The establishment of a system to ensure that all donated blood is screened for Transfusion transmissible infections is a core component of every blood transfusion setup. Blood safety depends on the recruitment and retention of blood donors who are at low risk of transmitting infection, safe blood collection procedures, reliable testing for transfusion-transmissible infections, blood grouping and compatibility testing, and the appropriate use and safe administration of blood. The World Health Organization Blood Transfusion safety program developed a plan of action to ensure blood safety, promote them at all levels, and provide support to member countries in achieving it.