Health products policy and standards
Our team provides authoritative guidance and standards on quality, safety and efficacy of health products and supports countries to formulate evidence-based policies and ensure good practice throughout the value chain.

Testing of donated blood

The first step in reducing the risk of transmission of infectious diseases through blood is to select voluntary non-remunerated donors from low-risk populations who give blood on a regular basis as these individuals are at a lower risk of transmitting transfusion-transmissible infections than are family/replacement donors, or paid donors. However, even with the most careful selection, some donors may be seropositive for HIV or other infectious agents. Therefore, rigorous screening of all donated blood is required to ensure the safety of the blood supply.

WHO recommends that all blood donations be screened for evidence of infection prior to the release of the blood and its components for clinical or manufacturing use. Screening of all blood donations should be mandatory for HIV, hepatitis B and C and syphilis.

The donated blood should also be tested for ABO and RhD to ensure the safety and compatibility of the transfusion for the patient.

WHO encourages and supports countries, through provision of advice and training, in the development and implementation of these activities in accordance with their needs.

WHO publications

Guidance on centralization of blood donation testing and processing

Multiple barriers to the safety and availability of blood components for transfusion were identified in the 2015 Global Database on Blood Safety, many...

Action framework to advance universal access to safe, effective and quality-assured blood products 2020–2023

In response to calls for action, WHO has provided guidelines, physical standards, training and technical support to improve blood product quality, safety...

Strategic framework for blood safety and availability

Blood transfusion is an essential component of health care that contributes to saving lives and improving the quality of life for millions of people worldwide....

Screening donated blood for transfusion-transmissible infections : recommendations

This document is designed primarily to support the strengthening and improvement of blood screening programmes in countries where systems are not yet...