Mental Health, Brain Health and Substance Use
Our work involves mental health promotion and the prevention of mental, neurological and substance use disorders. We support the expansion of access to affordable, quality care for everyone who needs it.
Antidepressant medication in comparison with psychological treatment for moderate-severe depressive disorder
2023 updated
Recommendation(s)
In adults with moderate-to-severe depression, psychological interventions or combined treatment should be considered based on individual preferences and careful consideration of the balance of benefits and harms. Antidepressant medicine alone for adults with depression (moderate-to-severe) should only be considered when psychological interventions are not available. Providers should keep in mind the possible adverse effects associated with antidepressant medicines, and individual preferences.
Strength of recommendation: CONDITIONALCertainty of the evidence: LOW