Mental Health, Brain Health and Substance Use
Our work involves mental health promotion and the prevention of mental, neurological and substance use disorders. We support the expansion of access to affordable, quality care for everyone who needs it.
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Antidepressants (Tricyclic Antidepressants [TCAs] and Selective Serotonin Reuptake Inhibitors [SSRIs]) in treatment of adults with depressive episode/disorder

2023 updated

Recommendation(s)

In adults with moderate-to-severe depression, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine or sertraline (SSRIs) or amitriptyline (TCA) should be considered

Strength of recommendation: CONDITIONAL

Certainty of evidence: VERY LOW

2012 validated

Recommendation(s)

Antidepressants should not be considered for the initial treatment of adults with a mild depressive episode.
Strength of recommendation: CONDITIONAL
Certainty of evidence: LOW

If drug treatment is required in older people, tricyclic antidepressants should be avoided if possible.
Strength of recommendation: CONDITIONAL
Certainty of evidence: LOW

If drug treatment is required in women with a depressive episode who are planning a pregnancy or pregnant or breastfeeding, tricyclic antidepressants or fluoxetine should be considered.
Strength of recommendation: CONDITIONAL
Certainty of evidence: LOW