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Millions of people take antiretroviral medicines to treat HIV infections. It’s vital that they all take their medicines regularly. If they don’t, the HIV virus can become resistant, and most effective and affordable medicines can stop working.
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Tackling HIV drug resistance

Millions of people around the world take antiretroviral medicines to treat HIV infections. It’s vital that they all take their medicines regularly. Sometimes it is difficult because people can’t always get hold of treatment when they need it. But if they don’t take it regularly, the HIV virus can become resistant.

This means, that the most effective and affordable medicines we have can stop working because the virus stops responding to the treatment. As a consequence, people have to switch to different drugs, which may be harder to obtain, or more expensive, or which may have more side effects.

Lack of action to prevent, monitor and respond to HIV drug resistance can block the world from meeting the 95-95-95 targets, to ensure that 95% of people receiving HIV treatment achieve suppression of the virus in their blood by 2030.

WHO’s Global Action Plan on HIV drug resistance 2017–2021, aligned with the global action plan on antimicrobial resistance, defines key actions for country and global stakeholders to prevent, monitor and respond to HIV drug resistance and to accelerate progress towards achieving the global targets for HIV epidemic control by 2030.

Up to 1 in 5 people

with ART failure

may have resistance to dolutegravir. Stay on treatment and test viral load to keep ART working.

10-fold higher risk

of drug resistance

if PrEP is started during undiagnosed HIV. Test before and during PrEP to stay safe and stop HIV.

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Events

Latest policy guidance

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Guidelines on the public health response to pretreatment HIV drug resistance
Supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: second edition June 2016
Global action plan on HIV drug resistance 2017–2021

Preventing and managing the emergence of HIVDR is a key component of a comprehensive and effective HIV response, and should be integrated into broader...

Publications

HIV drug resistance surveillance in countries scaling up pre-exposure prophylaxis – Second edition

WHO recommends pre-exposure prophylaxis (PrEP) as a prevention choice for individuals at substantial risk of acquiring HIV infection, as part of combination...

HIV drug resistance – brief report 2024

This brief report summarizes recent information on HIV drug resistance (HIVDR) in the era of integrase-strand transfer inhibitors (INSTI) for HIV...

Target product profile for HIV drug resistance tests in low- and middle-income countries: Africa

HIV-1 drug resistance tests may be useful tools for optimizing antiretroviral therapy (ART) regimens when used in the context of information about...

HIV drug resistance report 2021

HIV drug resistance (HIVDR) can compromise the effectiveness of antiretroviral therapy (ART) in reducing HIV incidence and HIV-associated morbidity and...

HIV drug resistance strategy, 2021 update

The emergence of HIV drug resistance can compromise the effectiveness of antiretroviral drugs in reducing HIV incidence and HIV-associated morbidity and...

HIV drug resistance surveillance in countries scaling up pre-exposure prophylaxis

WHO recommends that pre-exposure prophylaxis (PrEP) be offered as an additional prevention choice for HIV-negative individuals at substantial risk of HIV...

HIV drug resistance report 2019

 The rise in antimicrobial resistance (AMR) is one of the greatest threats to global health. If it is not urgently addressed, it may result in millions...

Global Action Plan on HIV Drug Resistance 2017–2021: 2018 progress report

The rise in antimicrobial resistance is a growing global health concern that requires collective and coordinated action. Minimizing the emergence and transmission...

HIV drug resistance report 2017

This second HIV drug resistance (HIVDR) report provides an update on recent population levels of HIVDR covering the period 2014–2016. The report...

Global report on early warning indicators of HIV drug resistance

With increasing global use of antiretroviral therapy (ART) to both treat and prevent HIV, and increasing global trends in HIV drug resistance (HIVDR),...

Surveillance of HIV drug resistance in adults initiating antiretroviral therapy - pre-treatment HIV drug resistance

WHO’s HIV Drug Resistance (HIVDR) Monitoring and Surveillance Strategy is a critical component of the public health approach to antiretroviral...

WHO HIV drug resistance steering group meeting

In order to review the outcomes of the consultative process to revise existing surveillance methods, a meeting of the HIV drug resistance (HIVDR) Steering...

Implementation & sustainability of HIV drug resistance surveillance in Africa

In 2004, WHO and the United States Centers for Disease Control and Prevention (US-CDC), in collaboration with HIVResNet, developed a global strategy...

HIV drug resistance report 2012

This report assesses the general levels of transmitted and acquired drug resistance in select geographical areas of low- and middle-income countries. It...